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Neocarzinostatin the past, present, and future of an anticancer drug by

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Published by Springer in Tokyo, New York .
Written in English


  • Zinostatin.,
  • Zinostatin.,
  • Antibiotics, Antineoplastic -- chemistry.,
  • Antibiotics, Antineoplastic -- pharmacokinetics.,
  • Neoplasms -- drug therapy.

Book details:

Edition Notes

StatementH. Maeda, K. Edo, N. Ishida (eds.).
ContributionsMaeda, H., Edo, K. 1950-, Ishida, N. 1923-
LC ClassificationsRC271.Z55 N46 1997
The Physical Object
Paginationxvi, 287 p. :
Number of Pages287
ID Numbers
Open LibraryOL1007223M
ISBN 104431701877
LC Control Number96047101

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About this book. Introduction. The 20th century has witnessed the great benefits of the development of antibi­ otics, which became a reality after World War IL More than 50 years ago I witnessed the miraculous therapeutic power of penicillin, when I was a student at the Tohoku University Medical School's Department of Bacteriology in Sendai. You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Abstract. The antitumor antibiotic neocarzinostatin (NCS), isolated from the culture filtrates of Streptomyces carzinostaticus variant F (Ishida et al., ), is an acidic single-chain polypeptide with a molecular weight of 10, (Meienhofer et al., a). Generation of superoxide free radical by neocarzinostatin and its possible role in DNA damage. Biochemistry , 25 (5), DOI: /bia Dipak Dasgupta and Irving H. Goldberg. Mode of reversible binding of neocarzinostatin chromophore to DNA: evidence for binding via the minor by:

Neocarzinostatin is a protein-small molecule complex composed of an enediyne chromophore tightly bound to a amino acid single chain protein. The complex possesses antiproliferative and antitumor activity. The chromophore is the active compound, which is responsible for DNA cleavage; while the apoprotein stabilizes and regulates the Missing: book. Neocarzinostatin has been shown to induce single- and double-strand DNA breaks []. The conjugation of neocarzinostatin to SMA drastically increases the half-life of the peptide and decreases its toxicity to the bone marrow []. Further to the amide bond between the NCS and SMA, the SMA inherently assumes the micellar configuration in eques solutions.   An efficient route to the neocarzinostatin chromophore aglycon has been developed. The present strategy involves a stereoselective intramolecular acetylide−aldehyde cyclization to form the C5−C6 bond, followed by efficient installation of α-epoxide, naphthoate, and carbonate functionalities. The C8−C9-olefin was introduced by using the Martin sulfurane Cited by: The structure below is called the neocarzinostatin core. For these questions, just consider the carbon framework, which is why the hydrogens are omitted 1st attempt Part 1 (1 point) ii See Periodic Table See Hint How many ơ bonds are in the carbon framework of this structure?

Purchase Strategies and Tactics in Organic Synthesis, Volume 12 - 1st Edition. Print Book & E-Book. ISBN , Strategies and Tactics in Organic Synthesis, Vol provides a forum for investigators to discuss their approach to the science and art of organic than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity . Neocarzinostatin (NCS) is a protein-small molecule complex composed of an enediyne chromophore tightly bound to a amino acid single chain g: book. Download Citation | (+)‐Neocarzinostatin | IntroductionMyers' Retrosynthetic Planning for the Synthesis of (+)−NeocarzinostatinMyers' Total Synthesis of (+)−NeocarzinostatinMechanistic.